NOTICE OF ANNUAL GENERAL MEETING

FORM OF PROXY FOR THE ANNUAL GENERAL MEETING TO BE HELD ON TUESDAY, JUNE 30, 2026

PROPOSED GRANTING OF GENERAL MANDATES TO ISSUE SHARES AND REPURCHASE SHARES&#x3b; PROPOSED RE-ELECTION OF RETIRING DIRECTORS AND PROPOSED ELECTION OF DIRECTOR&#x3b; PROPOSED RE-APPOINTMENT OF AUDITOR&#x3b; PROPOSED REFRESHMENT OF SCHEME MANDATE LIMIT AND SERVICE PROVIDER SUBLIMIT&#x3b; AND NOTICE OF ANNUAL GENERAL MEETING

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 May 2026

VOLUNTARY ANNOUNCEMENT FIRST PATIENT ENROLLMENT COMPLETED IN THE PHASE III CLINICAL TRIAL OF OT-802

GRANTS OF OPTIONS AND AWARDS

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 30 April 2026

2025 Annual Report

2025 Environmental, Social and Governance Report

Notification Letter to Non-registered Shareholders and Reply Form - Arrangement of Electronic Dissemination of Corporate Communications

Notification Letter to Registered Shareholders and Reply Form - Arrangement of Electronic Dissemination of Corporate Communications

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 March 2026

VOLUNTARY ANNOUNCEMENT FIRST PATIENT ENROLLMENT COMPLETED IN THE PHASE III CLINICAL TRIAL OF OT-211

RETIREMENT AND PROPOSED APPOINTMENT OF INDEPENDENT NON-EXECUTIVE DIRECTOR

ANNUAL RESULTS ANNOUNCEMENT FOR THE YEAR ENDED DECEMBER 31, 2025

DATE OF BOARD MEETING

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 28 February 2026

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 January 2026

VOLUNTARY ANNOUNCEMENT PATIENT ENROLLMENT COMPLETED IN THE REAL-WORLD STUDY OF OT-703 IN HAINAN BOAO

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 December 2025