Monthly Return of Equity Issuer on Movements in Securities for the Month ended 30 November 2022

POLL RESULTS OF THE EXTRAORDINARY GENERAL MEETING HELD ON NOVEMBER 25, 2022

(1) REFRESHMENT OF THE SCHEME MANDATE LIMIT AND SETOF THE SERVICE PROVIDER SUBLIMIT;(2) GRANT TO EMPLOYEE PARTICIPANTS AND CONNECTEDTRANSACTION INVOLVING THE PROPOSED CONNECTED GRANT;AND(3) NOTICE OF EXTRAORDINARY GENERAL MEETING

NOTIFICATION LETTER AND REQUEST FORM TO NON-REGISTERED SHAREHOLDERS

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 October 2022

FORM OF PROXY FOR THE EXTRAORDINARY GENERAL MEETING TO BE HELD ON FRIDAY, NOVEMBER 25, 2022

NOTIFICATION LETTER AND REQUEST FORM TO REGISTERED SHAREHOLDERS

Documents on Display Multi-Files

NOTICE OF EXTRAORDINARY GENERAL MEETING

DELAY IN DESPATCH OF CIRCULAR IN RELATION TO PROPOSED CONNECTED GRANT TO DIRECTORS UNDER THE 2021 SHARE AWARD SCHEME

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 30 September 2022

NOTIFICATION LETTER AND REQUEST FORM TO NON-REGISTERED SHAREHOLDERS

2022 Interim Report

NOTIFICATION LETTER AND REQUEST FORM TO REGISTERED SHAREHOLDERS

(I) GRANT OF OPTIONS UNDER THE 2021 SHARE OPTION SCHEME; (II) GRANT OF AWARDS TO EMPLOYEES UNDER THE 2021 SHARE AWARD SCHEME; AND (III) NON-EXEMPT CONNECTED TRANSACTION - PROPOSED CONNECTED GRANT TO DIRECTORS

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 August 2022

INTERIM RESULTS ANNOUNCEMENT FOR THE SIX MONTHS ENDED JUNE 30, 2022

NOTICE OF BOARD MEETING

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 July 2022

Next Day Disclosure Return

Next Day Disclosure Return

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 30 June 2022

POLL RESULTS OF THE ANNUAL GENERAL MEETING HELD ON JUNE 24, 2022

POLL RESULTS OF THE ANNUAL GENERAL MEETING HELD ON JUNE 24, 2022

INSIDE INFORMATION NEW DRUG APPLICATION OF OUR CORE PRODUCT OT-401 APPROVED BY THE NATIONAL MEDICAL PRODUCTS ADMINISTRATION

CHANGE OF JOINT COMPANY SECRETARY, AUTHORIZED REPRESENTATIVE AND PROCESS AGENT AND WAIVER FROM STRICT COMPLIANCE WITH RULES 3.28 AND 8.17 OF THE LISTING RULES

VOLUNTARY ANNOUNCEMENT CDE APPROVAL RECEIVED FOR A PHASE III CLINICAL TRIAL OF OT-703 IN CHINA

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 May 2022

DISCLOSEABLE TRANSACTION RELATING TO THE PROMOTION AGREEMENT WITH VIATRIS

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 30 April 2022

NOTIFICATION LETTER AND REQUEST FORM TO NON-REGISTERED SHAREHOLDERS

NOTIFICATION LETTER AND REQUEST FORM TO REGISTERED SHAREHOLDERS

FORM OF PROXY FOR THE ANNUAL GENERAL MEETINGTO BE HELD ON FRIDAY, JUNE 24, 2022

NOTICE OF ANNUAL GENERAL MEETING

PROPOSED GRANTING OF GENERAL MANDATES TO ISSUE SHARES AND REPURCHASE SHARES;PROPOSED RE-ELECTION OF RETIRING DIRECTORS; PROPOSED RE-APPOINTMENT OF AUDITOR; AND NOTICE OF ANNUAL GENERAL MEETING

2021 Environmental, Social and Governance Report

2021 Annual Report

List of Directors and their Role and Function

APPOINTMENT OF INDEPENDENT NON-EXECUTIVE DIRECTOR AND CHANGE IN COMPOSITION OF BOARD COMMITTEES

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 March 2022

List of Directors and their Role and Function

PASSING AWAY OF AN INDEPENDENT NON-EXECUTIVE DIRECTOR

ANNUAL RESULTS ANNOUNCEMENT FOR THE YEAR ENDED DECEMBER 31, 2021

DATE OF BOARD MEETING

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 28 February 2022

VOLUNTARY ANNOUNCEMENT PRIMARY CLINICAL ENDPOINT ACHIEVED IN THE PHASE III CLINICAL TRIAL OF OT-1001

VOLUNTARY ANNOUNCEMENT COOPERATION WITH VIATRIS ON DISTRIBUTION AND PROMOTION OF OPHTHALMIC DRUGS

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 January 2022

Monthly Return of Equity Issuer on Movements in Securities for the Month ended 31 December 2021